Palavra-chave: TWO-LAYER APPROACH

HYDROGENATION OPTIMIZATION DYNAMIC MODELING SIMULATION ADVANCED CONTROLLER DYNAMIC MODELLING HYDROGENATION, THREE-PHASE CATALYTIC REACTOR. HYDROGENATION CATALYTIC REACTOR DYNAMICS MODELING REAL TIME INTEGRATION ALGORITHMS AND SIMULATION INTEGRATION OF CONTROL AND OPTIMIZATION CONTROLLER ADVANCED GENETIC ALGORITHMS BIOTECHNOLOGICAL PROCESS MODEL-BASED CONTROL ACRYLIC ACID BIOPROCESS OPTIMAL OPERATIONAL FERMENTATION CONTROL