The main goal of our laboratory is to investigate the effects of multiparity and aging on cells and the extracellular matrix during postpartum recovery in the birth canal (including the pubic symphysis, uterine cervix, and vagina) in mice. We are particularly interested in understanding how childbirth and aging influence tissue homeostasis, as this knowledge could shed light on the pathophysiology of pelvic organ prolapse, urinary incontinence, and preterm birth. Our research focuses on connective tissue—an important hub for cellular, molecular, and hormonal signaling—and examines how it responds (or fails to respond) to changes occurring during and after first and multiple pregnancies. Through morphological, biochemical, and molecular analyses, we have found that recovery processes in the birth canal are actively regulated by cells and molecular pathways, and that both multiparity and aging impair these recovery mechanisms in the reproductive tissues of mice.