Ciências Biológicas
Synthetic Biology and Yeast-based Drug DiscoveryWe employ Saccharomyces cerevisiae as a platform for drug discovery. We perform chemical genomic profiling for the identification of the mode of action of novel antiparasitic or antibiotic agents (synthetic or natural compounds). We engineer yeast strains to express antiparasitic drug targets and perform high-throughput drug screens to identify promising compounds. In a third line of investigation, we humanize yeast strains to express human proteins prone to aggregation to identify inhibitors of aggregates. This is combined with the humanization of the plasma membrane of the yeast and expression of human blood-brain-barrier transporters, in order to pinpoint how drugs may cross the human BBB.
We also use deep-learning and synthetic biology to develop novel enzymes for secondge
Italiano | Compreende Bem , Fala Razoavelmente , Lê Razoavelmente , Escreve Pouco |
Inglês | Compreende Bem , Fala Bem , Lê Bem , Escreve Bem |
Sueco | Compreende Bem , Fala Razoavelmente , Lê Bem , Escreve Pouco |
Alemão | Compreende Pouco , Fala Pouco , Lê Razoavelmente , Escreve Pouco |
Português | Compreende Bem , Fala Bem , Lê Bem , Escreve Bem |
Apoio FAPESP em números
1 | 2 | 8 | 1 | 13 | 12 |
---|---|---|---|---|---|
Auxílios à pesquisa em andamento | Auxílios à pesquisa concluídos | Bolsas no país concluídas | Bolsas no exterior concluídas | Todos os Auxílios e Bolsas | Todos os Auxílios e Bolsas |