Ciências Exatas e da Terra
Targeted metallodrugs for the treatment of diseasesDr. Abbehausen research interests include all aspects of Bioinorganic Chemistry such as understanding the structure and mechanism of action of metalloenzymes and metalloproteins and the use of metallodrugs to treat diseases. Concerning the latter, we seek to rationalize the design of metal complexes and organometallics to be specifically targeted.
• The study of the mechanism of action of metalloenzymes and metalloproteins. Recently we have been focusing on zinc finger domains in proteins, metallo-betalactamases and superoxide dismutase;
• The design of specific inhibitors for these metalloproteins;
• The design of metal-based compounds for the treatment of cancer, and bacterial and parasitic diseases;
• The use of multiple tec
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Apoio FAPESP em números
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