MULTIVARIATE REGRESSION TECHNIQUES BIOREACTORS ALCOHOLIC FERMENTATION MODELLING NONLINEAR CONTROL MATHEMATICAL MODELING HYBRID NEURAL MODELLING PROCESS SIMULATION MULTIVARIABLE PREDICTIVE CONTROL RESIDUAL TREATMENT HYBRID MODELING ZYMOMONAS MOBILIS NEURAL NETWORKS EXTRACTIVE ALCOHOLIC FERMENTATION KINETIC PARAMETERS ESTIMATION THREE-PHASE CATALYTIC REACTOR MATHEMATICAL MODELLING NON-LINEAR PREDICTIVE CONTROL